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130. Discovery of 5-sulfonyltetrazoles as neuroblastoma differentiation agents. Johns, A. C.; Oviedo, A.; Zhao, Z.; Du, L.; Kornienko, A. Bioorg. Med. Chem. Lett. 2023, 94, 129455.link
129. Convenient synthesis of (Z)-3-(1-aryl-2-nitrovinyl)-indoles. Arutiunov, N. A.; Aksenov, A. V.; Aksenov, D. A.; Kurenkov, I. A.; Aksenova, I. V.; Zatsepilina, A. M.; Aksenov, N. A.; Kornienko, A. Tetrahedron Lett. 2023, 129, 154722. link
128. Synthesis of beta-carbolines with electrocyclic cyclization of 3-nitrovinylindoles. Aksenov, N. A.; Arutiunov, N. A.; Aksenov, A. V.; Kirilov, N. K.; Aksenova, I. V.; Aksenov, D. A.; Aleksandrova, E. V.; Kornienko, A. Int. J. Mol. Sci. 2023, 24, 13107. link
127. 4′H‐Spiro[indole-3,5′-isoxazoles] En Route to 2‐(1H‐Indol-3-yl)acetamides with Anticancer Activities. Aksenov, A.; Kirilov, N.; Arutuinov, N.; Aksenov, D.; Kuzminov, I.; Aksenov, N.; Turner, D. N.; Rogelj, S.; Kornienko, A.; Rubin, M. J. Org. Chem. 2022, 87, 13955.link
126. Medicinal chemical optimization of fluorescent pyrrole-based COX-2 probes. Wagh, S. B.; Maslivetc, V.; La Clair, J. J.; Kornienko, A. Tetrahedron 2022, 123, 132990.link
125. Conversion of natural narciclasine to its C-1 and C-6 derivatives and their antitumor activity evaluation: some unusual chemistry of narciclasine. Stollmaier, J. G.; Thomson, J.; Endoma-Arias, M. A.; Simionescu, R.; Vernaza, A.; Mesa-Diaz, N.; Smith, M.; Du, L.; Kornienko, A.; Hudlicky, T. Molecules 2022, 27, 4141.link
124. Design and synthesis of C-1 methoxycarbonyl derivative of narciclasine and its biological activity. Habaz, L.; Bedard, K.; Smith, M.; Du, L.; Kornienko, A.; Hudlicky, T. Molecules 2022, 27, 3809.link
123. Polygodial, a Sesquiterpene Dialdehyde, Activates Apoptotic Signaling in Castration‐Resistant Prostate Cancer Cell Lines by Inducing Oxidative Stress. Venkatesan, R.; Hussein, M. A.; Moses, L.; Liu, J.; Khetani, S.; Kornienko, A.; Munirathinam, G. Cancers 2022,14, 5260.link
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121. In Vitro Effects of fungal phytotoxins on cancer cell viability: first insight into structure activity relationship of a potent metabolite of Cochliobolus australiensis radicinin. Mathieu, V.; Superchi, S.; Masi, M.; Scafato, P.; Kornienko, A.; Evidente, A. Toxins 2022,14, 517.link
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119. Synthesis and biological evaluation of 10-benzyloxy-narciclasine. Ticli, V.; Zhao, Z.; Du, L.; Kornienko, A.; Hudlicky, T. Tetrahedron 2021,101, 132505.link
118. Polygodial and ophiobolin A analogues for covalent crosslinking of anticancer targets. Maslivetc, V.; Laguera, B.; Chandra, S.; Dasari, R.; Olivier, W. J.; Smith, J. A.; Bissember, A. C.; Masi, M.; Evidente, A.; Mathieu, V.; Kornienko, A. Int. J. Mol. Sci. 2021, 22, 11256.link
117. Lessons in organic fluorescent probe discovery. Wagh, S. B.; Maslivetc, V.; La Clair, J. J.; Kornienko, A. ChemBioChem 2021, 22, 3109-3139. link
116. [3+2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor. Aksenov, A. V.; Arutiunov, N. A.; Kirilov, N. K.; Aksenov, D. A.; Grishin, I. Yu.; Aksenov, N. A.; Wang, H.; Du, L.; Betancourt, T.; Pelly, S. C.; Kornienko, A.; Rubin, M. Org. Biomol. Chem. 2021,19, 7234-7245. link
115. Epithelial-mesenchymal transition sensitizes breast cancer cells to cell death via the fungus-derived sesterterpenoid ophiobolin A. Reisenauer, K. N.; Tao, Y. F.; Das, P.; Song, S. X.; Svatek, H.; Patel, S. D.; Mikhail, S.; Ingros, A.; Sheesley, P.; Masi, M.; Boari, A.; Evidente, A.; Kornienko, A.; Romo, D.; Taube, J. Sci. Rep. 2021,11, 10652. link
114. A fluorescent target-guided Paal–Knorr reaction. Wagh, S. B.; Maslivetc, V.; La Clair, J. J.; Kornienko, A. RSC Adv., 2020, 10, 37035-37039. link
113. Deciphering the chemical instability of sphaeropsidin A under physiological conditions – degradation studies and structural elucidation of the major metabolite. Van der Westhuyzen, A. E.; Ingels, A.; Rosiere, R.; Amighi, K.; Oberer, K., Gustafson, K. R.; Wang, D.; Evidente, A.; Maddau, L.; Masi, M.; de Villiers, A.; Green, I. R.; Berger, W.; Kornienko, A.; Mathieu, V.; van Otterlo, W. A. L. Org. Biomol. Chem., 2020, 18, 8147-8160. link
112. A new series of acetohydroxamates shows in vitro and in vivo anticancer activity against melanoma. Segat, G. C.; Moreira, C. G.; Santos, E. C.; Heller, M.; Schwanke, R. C.; Aksenov, A. V.; Aksenov, N. A.; Aksenov, D. A.; Kornienko, A.; Marcon, R.; Calixto, J. B. Invest. New Drugs, 2020, 38, 977-989. link
111. Nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity. Aksenov, N. A.; Aksenov, A. V.; Kirilov, N. K.; Arutiunov, N. A.; Aksenov, D. A.; Maslivetc, V.; Zhao, Z.; Du, L.; Rubin, M.; Kornienko, A. Org. Biomol. Chem. 2020, 18, 6651-6664. link
110. Antiproliferative activity of naphthoquinones and indane carboxylic acids from lapachol against a panel of human cancer cell lines. Eyong, K. O.; Ketsemen, H. L.; Zhao, Z.; Du, L.; Ingels, A.; Mathieu, V.; Kornienko, A.; Hull, K. G.; Folefoc, G. N.; Baskaran, S.; Romo, D. Med. Chem. Res. 2020, 29, 1058-1066. link
109. Synergistic action of substituted indole derivatives and clinically used antibiotics against drug-resistant bacteria. Turner, D. N.; Edwards, L.; Kornienko, A.; Frolova, L. V.; Rogelj, S. Future Med. 2020, 15, 579-590. link
108. Photo-uncaging of a microtubule-targeted rigidin analogue in hypoxic cancer cells and in a xenograft mouse model. van Rixel, V. H. S.; Ramu, V.; Auyeung, A. B.; Beztsinna, N.; Leger, D. Y.; Lameijer, L. N.; Hilt, S. T.; Le Devedec S. E.; Yilidiz, T.; Betancourt, T.; Gildner, M. B.; Hudnall, T. W.; Sol, V.; Liagre, B.; Kornienko, A.; Bonnet, S. J. Am. Chem. Soc. 2019, 141, 18444-18454. link
107. A brief up-to-date overview of Amaryllidaceae alkaloids: phytochemical studies of Narcissus tazetta subsp. tazetta L., collected in Turkey. Karakoyun, C.; Masi, M.; Cimmino, A.; Ali Onur, M.; Somer, N. U.; Kornienko, A.; Evidente, A. Nat. Prod. Commun. 2019, 1-6. Link
106. Marine-Derived Anticancer Agents: Clinical Benefits, Innovative Mechanisms, and New Targets. Pereira, R. B.; Evdokimov, N. M.; Lefranc, F.; Valentao, P.; Kornienko, A.; Pereira, D.; Andrade, P. B.; Gomes, N. G. M. Mar. Drugs 2019, 17, 329. link
105. Chemistry and biology of ophiobolin A and its congeners. Masi, M.; Dasari, R.; Evidente, A.; Mathieu, V.; Kornienko, A. Bioorg. Med. Chem. Lett. 2019, 29, 859-869. link
104. Synthesis of spiro[indole-3,5’-isoxazoles] with anticancer activity via formal (4+1)-spirocyclization of nitroalkenes to indoles. Aksenov, A. V.; Aksenov, D. A.; Arutiunov, N. A.; Aksenov, N. A.; Aleksandrova, E. V.; Zhao, Z.; Du, L; Kornienko, A.; Rubin, M. J. Org. Chem. 2019, 84, 7123-7137. link
103. Activity of natural and synthetic polygodial derivatives against Trypanosoma cruzi amastigotes, trypomastigotes and epimastigotes. Turner, D. N.; Just, J.; Dasari, R.; Smith, J. A.; Bissember, A. C.; Kornienko, A.; Rogelj, S. [1] D. N. Turner, J. Just, R. Dasari, J. A. Smith, A. C. Bissember, A. Kornienko, S. Rogelj, Nat. Prod. Res. 2019, 1-4. link
102. Alkaloids isolated from Haemanthus humilis Jacq., an indigenous South African Amaryllidaceae: Anticancer activity of coccinine and montanine. Mochel, J.; Heliso, P.; Gunawardana, S.; Masi, M; James, P.; Albalawi, A.; Van slambrouck, S.; van Otterlo, W. A. L.; Green, I.; Cimmino, A.; van Rensburg, M. J.; Kornienko, A.; Evidente, A. S. Afr. J. Bot. 2019, 277-281. link
101. Microtubule-targeting 7-deazahypoxanthines derived from marine alkaloid rigidins: exploration of the N3- and N9 positions and interaction with multidrug resistance proteins. Dasari, R.; Blauz, A.; Medelin, D.; Kassim, R.; Viera, C.; Santarosa, M.; Van der Westhuyzen, A.; van Otterlo, W. A. L.; Olivas, T.; Yildiz, T.; Betancourt, T.; Shuster, C. B.; Rogelj, S.; Rychlik, B.; Hudnall, T. Frolova, L.; Kornienko, A. ChemMedChem, 2019, 14, 322-333. link
100. Algae metabolites: from in vitro growth inhibitory effects to promising anticancer activity. Lefranc, F.; Koutsaviti, A.; Ioannou, E.; Kornienko, A.; Roussis, V.; Kiss, R.; Newman, D. J. Nat. Prod. Rep. 2019, 36(5): 810-841. link
99. A nitroalkane-based approach to one-pot three-component synthesis of isocyptolepine and its analogs with potent anti-cancer activities. Aksenov, N. A.; Aksenov, A. V.; Kornienko, A.; De Carvalho, A.; Mathieu, V.; Aksenov, D. A.; Ovcharov, S. N.; Griaznov, G. D.; Rubin, M. RSC Adv. 2018, 8, 36980. link
98. Novel polygodial analogs P3 and P27: Efficacious therapeutic agents disrupting mitochondrial function in oral squamous cell carcinoma. De La Chapa, J.; Singha, P. K.; Sallaway M.; Self, K.; Nasreldin, R.; Dasari, R.; Hart. M.; Kornienko, A.; Just, J.; Smith, J. A.; Bissimber, A. C.; Gonzales, C. B. Int. J. Oncol. 2018, 53, 2627- 2636. link
97. Photoactivated 2,3-distyrilindoles kill multi-drug resistant bacteria. Edwards, L.; Turner, D.; Champion, C.; Khandelwal, M.; Zingler, K.; Stone, C.; Rajapaksha, R. D.; Yang, J.; Ranasinghe, M. I.; Kornienko, A.; Frolova, L.; Rogelj, S. Bioorg. Med. Chem. Lett. 2018, 28, 1879-1886. link
96. Effect of polygodial and its direct derivatives on the mammalian Na+/K+-ATPase activity. Garcia, D. G.; Goncalves-de-Albuquerque, C. F.; da Silva C. I.; Kiss, R.; Dasari, R.; Chandra, S.; Kornienko, A.; Burth, P. Eur. J. Pharmacol. 2018, 831, 1-8. link
95. Polygodial analog induces apoptosis in LNCaP prostate cancer cells. Dasari, S.; Samy, A. L. P. A.; Narvekar, P.; Dontaraju, V. S.; Dasari, R.; Kornienko, A.; Munirathinam, G. Eur. J. Pharmacol. 2018, 828, 154-162. link
94. Novel topologically complex scaffold derived from alkaloid haemanthamine. Govindaraju, K.; Masi, M.; Colin, M.; Mathieu, V.; Evidente, A.; Hudnall, T. W.; Kornienko, A. Molecules, 2018, 23, 255. link
93. Synthetic analogues of the montanine-type alkaloids with activity against apoptosis-resistant cancer cells. Govindaraju, K.; Ingels, A.; Hasan, M. N.; Sun, D.; Mathieu, V.; Masi, M.; Evidente, A.; Kornienko, A. Bioorg. Med. Chem. Lett. 2018, 28, 589-593. link
92. The Amaryllidaceae alkaloid haemanthamine binds the eukaryotic ribosome to repress cancer cell growth. Pellegrino, S.; Meyer, M.; Zorbas, C.; Bouchta, S. A.; Saraf, K.; Pelly, S. C.; Yusupova, G.; Evidente, A.; Mathieu, V.; Kornienko, A.; Lafontaine, D. L. J.; Yusupov, M. Structure, 2018, 26, 416-425. link
91. Aspergillus candidis is a newly recognized source of sphaeropsidin A: Isolation, semisynthetic derivatization and anticancer evaluation. Li, Y.; Scott, R.; Hooper, A.; Bartholomeusz, G. A.; Kornienko, A.; Bills, G. F. Bioorg. Med. Chem. Lett. 2017, 27, 5436-5440. link
90. Covalent modification of biological targets with natural products through Paal-Knorr pyrrole formation. Kornienko, A.; La Clair, J. J. Nat. Prod. Rep. 2017, 34, 1051-1060. link
89. Irreversible protein labeling by Paal-Knorr conjugation. Dasari, R.; La Clair, J. J.; Kornienko, A. ChemBioChem. 2017, 18, 1792-1796.
88. One-pot, three-component assembly of indoloquinolines: Total synthesis of isocryptolepine. Aksenov, A.; Aksenov, D.; Orazova, N.; Aksenov, N.; Griaznov, G.; de Carvalho, A.; Kiss, R.; Mathieu, V.; Kornienko, A.; Rubin, M. J. Org. Chem. 2017, 82, 3011-3018.
87. A harmine-derived beta-carboline displays anticancer effects in vitro by targeting protein synthesis. Carvalho, A.; Chu, J.; Meinguet, C; Kiss, R.; Vandenbussche, G.; Massereel, B.; Wouters, J.; Kornienko, A.; Pelletier, J.; Mathieu, V. Eur. J. Pharmacol. 2017, 805, 25-35.
86. Marine Mollusk-derived agents with antiproliferative activity as promising anticancer agents to overcome chemotherapy resistance. Ciavatta, M. L.; Lefranc, F.; Carbone, M.; Mollo, E.; Gavagnin, M.; Betancourt, T.; Dasari, R.; Kornienko, A.; Kiss, R. Med. Res. Rev. 2017, 37, 702-801.
85. Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities. Medellin, D. C.; Zhou, Q.; Scott, R.; Hill, R. M.; Frail, S. K.; Dasari, R.; Ontiveros, S. J.; Pelly, S. C.; van Otterlo, W. A. L.; Betancourt, T. B.; Shuster, C. B.; Hamel, E.; Bai, R.; LaBarbera, D. V.; Rogelj, S.; Frolova, L. V.; Kornienko, A. J. Med. Chem. 2016, 59, 480-485.
84. Single dish gradient screening of small molecule localization. Beuzer, P.; Axelrod, J.; Trzoss, L; Fenical, W.; Dasari, R.; Evidente, A.; Kornienko, A.; Cang, H.; La Clair J. J. Org. Biomol. Chem. 2016, 14, 8241-8245.
83. Marine invertebrate metabolites with anticancer acitivities: solutions to the “supply problem.” Gomes, N. G. M.; Dasari, R.; Chandra, S.; Kiss, R.; Kornienko, A. Mar. Drugs 2016, 14, 98.
82. 5,10b-Ethanophenanthridine Amaryllidaceae Alkaloids Inspire the Discovery of Novel Bicyclic Ring Systems with Activity against Drug Resistant Cancer Cells. Henry, S.; Kidner, R.; Reisenauer, M. R.; Magedov, I. V.; Quintana, R.; Kiss, R.; Mathieu, V.; Lefranc, F.; Dasari, R.; Evidente, A.; Yu, X.; Ma, X.; Pertsemlidis, A.;
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81. Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides. Panayides, J. L.; Mathiu, V.; Banuls, L. M. Y.; Apostolellis, H.; Dahan-Farkas, N.; Davids, H.; Harmse, L.; Rey, E. M. C.; Green, I. R.; Pelly, S. C.; Kiss, R.; Kornienko, A.; van Otterlo, W. A. L. Bioorg. Med. Chem. 2016, 24, 2716-
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80. Crystal structure and absolute configuration of sphaeropsidin A and its 6-O-p-bromobenzoate. Masi, M.; Cimmino, A.; Maddau, L.; Kornienko, A.; Tuzi, A.; Evidente A. Tetrahedron Lett. 2016, 57, 4592-4594.
79. Isatin derivatives with activity against apoptosis-resistant cancer cells. Evdokimov, N. M.; Magedov, I. V.; McBrayer, D.; Kornienko, A. Bioorg. Med. Chem. Lett. 2016, 26, 1558-1560.
78. Higginsianins A and B, Two Diterpenoid alpha-Pyrones Produced by Colletotrichum higginsianum, with in Vitro Cytostatic Activity. Cimmino, A.; Mathieu, V.; Masi, M.; Baroncelli, R.; Boari, A.; Pescitelli, G.; Ferderin, M.; Lisy, R.; Evidente, M.; Tuzi, A.; Zonno, M. C.; Kornienko, A.; Kiss, R.; Evidente, A. J. Nat. Prod. 2016, 79, 116-125.
77. Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates Against Drug-Resistant Cancer Cells. Aksenov, A. V.; Smirnov, A. N.; Magedov, I. V.; Reisenaur, M. R.; Aksenov, N. A.; Aksenova, I. V.; Nguyen, G.; Johnston, R. K.; Rubin, M.; Kiss, R.; Mathieu, V.; Lefranc, F.; Correa, J.; Cavazos, D. A.; Brenner, A. J.; Rogelj, S.;
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76. Wittig Derivatization of Sesquiterpenoid Polygodial Leads to Cytostatic Agents with Activity Against Drug Resistant Cancer Cells and Capable of Pyrrolylation of Primary Amines. Dasari, R.;De Carvalho, A.; Medellin, D. C.; Middleton, K. N.; Hague, F.; Volmar, M. N. M.; Frolova, L. V.;Rossato, M. F.; Mathieu, V.;Rogelj, S.;
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75. Synthetic and Biological Studies of Sesquiterpene Polygodial: Activity of 9-Epipolygodial Against Drug Resistant Cancer Cells. Dasari, R.;De Carvalho, A.; Medellin, D. C.;Middleton, K. N.;Hague, F.;Volmar, M. N. M.; Frolova, L. V.;Rossato, M. F.; Mathieu, V.;Rogelj, S.;Gonzales, C. B.; Calixto, J. B.; Evidente, A.; Gautier,
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74. Fungal Metabolite Ophiobolin A as a Promising Anti-Glioma Agent: In Vivo Evaluation, Structure-Activity Relationship and Unique Pyrrolylation of Primary Amines. Dasari, R.; Masi, M.; Lisy, R.; Ferderin, M.; English, L. R.; Cimino, A.; Mathieu, V.; Brenner, A.; Kuhn, J. G.; Whitten, S. T.; Evidente, A.; Kiss, R.; Kornienko,
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72. Sphaeropsidin A shows promising activity against drug-resistant cancer cells by targeting regulatory volume increase. Mathieu, V.; Chantome, A.; Lefranc, F.; Cimmino, A.; Miklos, W.; Paulitschke, V.; Mohr, T.; Maddau, L.; Kornienko, A.; Berger, W.; Vandier, C.; Evidente, A.; Delpire, E.; Kiss, R. Cell. Mol. Life Sci. 2015, 72,
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71. Lipophilic prodrug conjugates allow facile and rapid synthesis of high-loading capacity liposomes without the need for post-assembly purification. Mikhalin, A. A.; Evdokimov, N. M.; Frolova, L. V.; Magedov, I. V.; Kornienko, A.; Johnston, R.; Rogelj, S.; Tartis, M. S. J. Liposome Res. 2015, 25, 232-260.
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69. Jonquailine, a new pretazettine-type alkaloid isolated from Narcissus jonquilla quail, with activity against drug-resistant cancer. Masi, M.; Frolova, L. V.; Yu, X.; Mathieu, V.; Cimmino, A.; De Carvalho, A.; Kiss, R.; Rogelj, S.; Pertsemlidis, A.; Kornienko, A.; Evidente, A. Fitoterapia 2015, 102, 41-48.
68. Synthetic and Biological Studies of Tubulin Targeting C2-Substituted 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins. Scott, R.; Karki, M.; Reisenauer, M. R.; Rodrigues, R.; Dasari, R.; Smith, W. R.; Pelly, S. C.; van Otterlo, W. A. L.; Shuster, C. B.; Rogelj, S.; Magedov, I. V.; Frolova, L. V.; Kornienko, A. ChemMedChem, 2014, 9, 1428-1435.
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66. C-H Functionalization Directed by Transformable Nitrogen Heterocycles: Synthesis of ortho-Oxygenated Arylnaphthalenes from Arylphthalazines. Rastogi, S. K.; Medellin, D. C.; Kornienko, A. Org. Biomol. Chem. 2014, 12, 410-413.
65. First Multicomponent Synthesis of Pyrrolo[2,3-d]pyrimidines. Dasari, R.; Kornienko, A. Chem. Heterocycl. Comp. 2014, 160-165.
64. Synthesis of 4-azapodophyllotoxins with anticancer activity by multicomponent reactions. Botes, M. G.; Pelly, S. C.; Blackie, M. A. L.; Kornienko, A.; van Otterlo, W. A. L. Chem. Heterocycl. Comp. 2014, 139.
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61. Perspective: Therapeutic Agents Triggering Non-Apoptotic Cancer Cell Death. Kornienko, A.; Mathieu, V.; Rastogi, S.; Lefranc, F.; Kiss, R. J. Med. Chem. 2013, 56, 4823.
60. Metal-Free Transannulation Reaction of Indoles with Nitrostyrenes: A Simple Practical Synthesis of 3- Substituted 2-Quinolones. Aksenov, A. V.; Smirnov, A. N.; Aksenov, N. A.; Aksenova, I. V.; Frolova, L. V.; Kornienko, A.; Magedov, I. V.; Rubin, M. Chem. Commun. 2013, 49, 9305.
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56. Narciclasine as well as other Amaryllidaceae Isocarbostyrils are Promising GTPase-Targeting Agents against Brain Cancers. Van Goietsenoven, G. ; Mathieu, V. ; Lefranc, F. ; Kornienko, A.; Evidente, A. ; Kiss, R. Med. Res. Rev. 2013, 33, 439.
55. Narciclasine. Jucov, E.; Kornienko, A.; Masi, M.; Evidente, A.; Antipin, M.; Acta Cryst. E. 2013, E69, o9–o10.
54. Reengineered Epipodophyllotoxin. Magedov, I. V.; Evdokimov, N. M.; Karki, M.;Peretti, A. S.;Lima, D. T.; Frolova, L.;Reisenauer, M. R.;Romero, A. E.;Tongwa, P.;Fonari, A.;Altig, J.;Rogelj, S.;Antipin, M. Y.;Shuster, C. B.;Kornienko, A. Chem. Commun. 2012, 48, 10416.
53. Unnatural C-1 homologues of pancratistatin: Synthesis and promising biological activities. Vshyvenko, S.; Scattolon, J.; Hudlicky, T.; Romero, A. E.; Kornienko, A.; Ma, D.; Griffin, G.; Pandey, S. Can. J. Chem. 2012, 90, 932.
52. Structural Simplification of Bioactive Natural Products with Multicomponent Synthesis. 4. 4H-Pyrano-[2,3-b]naphthoquinones with Anticancer Activity. Magedov,I. V.; Kireev, A. S.; Jenkins, A. R.; Evdokimov, N. M.; Lima, D. T.; Tongwa, P.; Altig, J.; Steelant, W. F. A.; Van slambrouck, S.; Antipin, M. Y.; Kornienko, A. Bioorg. Med. Chem. Lett. 2012, 22, 5195.
51. Bulbispermine: A Crinine-Type Amaryllidaceae Alkaloid Exhibiting Cytostatic Activity towards ApoptosisResistant Glioma Cells. Luchetti, G.; Johnston, R.; Mathieu, V.; Lefranc, F.; Hayden, K.; Andolfi, A.; LamoralTheys, D.; Reisenauer, M. R.; Champion, C.; Pelly, S. C.; van Otterlo, W. A. L.; Magedov, I. V.; Kiss, R.; Evidente, A.; Rogelj, S.; Kornienko, A. ChemMedChem, 2012, 7, 815.
50. Phenazines and Cancer. Cimmino, A.; Evidente, A.; Mathieu, V.; Andolfi, A.; Lefranc, F.; Kornienko, A.; Kiss, R. Nat. Prod. Rep. 2012, 29, 487.
49. Synthesis and Anticancer, Antimetastatic Evaluation of Some New Fluorinated Isocoumarins and 3,4-Dihydroisocoumarins. Abid, O. R.; Khalid, M.; Hussain, M. T.; Hanif, M.; Quadeer, G.; Rama, N. H.; Kornienko, A.; Khan, K. M. J. Fluor. Chem. 2012, 135, 240.
48. Multicomponent Reactions in Alkaloid-Based Drug Discovery. Magedov, I. V.; Kornienko, A. Chem. Heterocycl. Comp. 2012, 38.
47. In Search of a Cytostatic Agent Derived from the Alkaloid Lycorine: Synthesis and Growth Inhibitory Properties of Lycorine Derivatives. Evdokimov, N.; Lamoral-Theys, D.; Mathieu, V.; Andolfi, A.; Pelly, S.; van Otterlo, W.; Magedov, I.; Kiss, R.; Evidente, A.; Kornienko, A. Bioorg. Med. Chem. Lett. 2011, 19, 7252.
46. Multicomponent synthesis of 2,3-dihydrochromeno[4,3-d]pyrazolo[3,4-b]pyridine-1,6-diones: a novel heterocyclic scaffold with antibacterial activity. Frolova, L. V.; Malik, I.; Uglinskii, P. Y.; Rogelj, S.; Kornienko, A.; Magedov. I. V. Tetrahedron Lett. 2011, 52, 6643.
45. Synthesis of C-1 Homologues of Pancratistatin and their Preliminary Biological Evaluation. Vshyvenko, S.; Scattolon, J.; Hudlicky, T.; Romero, A. E.; Kornienko, A. Bioorg. Med. Chem. Lett. 2011, 21, 4750.
44. Aryliodine (III) Diacetates as Substrates for Pd-Ag Catalyzed Arylation of Alkenes. Evdokimov, N. M.; Kornienko, A.; Magedov, I. V. Tetrahedron Lett. 2011, 52, 4327.
43. Unprecedented C-2 Arylation of Indole with Diazonium Salts: Syntheses of 2,3-Disubstituted Indoles and their Antimicrobial Activity. Seth, D.; Hayden, K.; Malik, I.; Porch, N.; Tang, H.; Rogelj, S.; Frolova, L. V.; Lepthien, K.; Kornienko, A.; Magedov, I. V. Bioorg. Med. Chem. Lett. 2011, 21, 4720.
42. Anticancer Properties of an Important Drug Lead Podophyllotoxin Can Be Efficiently Mimicked by Diverse Heterocyclic Scaffolds Accessible via One-Step Synthesis. Magedov, I. V.; Frolova, L.; Manpadi, M.; Bhoga, U. D.; Tang, H.; Evdokimov, N. M.; George, O.; Georgiou, K. H.; Renner, S.; Getlic, M.; Kinnibrugh, T. L.; Fernandes, M. A.; van Slambrouck, S.; Steelant, W. F. A.; Shuster, C. B.; Rogelj, S.; van Otterlo, W. A. L.; Kornienko, A. J. Med. Chem. 2011, 54, 4234.
41. Structural Simplification of Bioactive Natural Products with Multicomponent Synthesis. 3. Fused UracilContaining Heterocycles as Novel Topoisomerase-Targeting Agents. Evdokimov, N. M.; Van slambrouck, S.; Heffeter, P.; Tu, L.; Le Calve, B.; Lamoral-Theys, D.; Hooten, C. J.; Uglinskii, P. Y.; Rogelj, S.; Kiss, R.;
Steelant, W. F. A.; Berger, W.; Yang, J. J.; Bologa, C. J.; Kornienko, A.; Magedov, I. V. J. Med. Chem. 2011, 54, 2012.
40. One-Pot Multicomponent Synthesis of Diversely Substituted 2-Aminopyrroles. A short General Synthesis of Rigidins A, B, C, and D. Frolova, L. V.; Evdokimov, N. M.; Hayden, K.; Malik, I.; Rogelj, S.; Kornienko, A.; Magedov, I. V. Org. Lett. 2011, 13, 1118.
39. Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas. Van Goietsenoven, G.; Hutton, J.; Becker, J.-P.; Lallemand, B.; Robert, F.; Lefranc, F.; Pirker, C.; Vandenbussche, G.; Van Antwerpen, P.; Evidente, A.; Berger, W.; Prévost, M.; Pelletier, J.; Kiss, R.; Kinzy, T. G.; Kornienko, A.; Mathieu, V. FASEB J. 2010, 24, 4575.
38. Amaryllidaceae Alkaloids Belonging to Different Structural Subgroups Display Activity against ApoptosisResistant Cancer Cells. Van Goietsenoven, G.; Andolfi, A.; Lallemand, B.; Cimmino, A.; Lamoral-Theys, D.; Gras, T.; Abou-Donia, A.; Dubois, J.; Lefranc, F.; Mathieu, V.; Kornienko, A.; Kiss, R.; Evidente, A. J. Nat. Prod. 2010, 73, 1223.
37. Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli. Lamoral-Theys, D.; Pottier, L.; Kerff, F.; Dufrasne, F.; Proutiere, F.; Wauthoz, N.; Neven, P.; Ingrassia, L.; Van Antwerpen, P.; Lefranc, F.; Gelbcke, M.; Pirotte, B.; Kraus, J. L.; Neve, J.; Kornienko, A.; Kiss, R.; Dubois, J. Bioorg. Med. Chem. 2010, 18, 3823.
36. Chemoenzymatic Synthesis of Amaryllidaceae Constituents and Biological Evaluation of their C-1 Analogues. The Next Generation Synthesis of 7-Deoxypancratistatin and trans-Dihydrolycoricidine. Collins, J.; Rinner, U.; Moser, M.; Hudlicky, T.; Ghiviriga, I.; Romero, A. E.; Kornienko, A.; Ma, D.; Griffin, C.; Pandey, S. J. Org. Chem. 2010, 75, 3069.
35. Lycorine and its Derivatives for Anticancer Drug Design. Lamoral-Theys, D.; Decaestecker, C.; Mathieu, V.; Dubois, J.; Kornienko, A.; Kiss, R.; Evidente, A.; Pottier, L. Mini-Rev. Med. Chem. 2010, 10, 41.
34. Natural Polyphenols that Display Anticancer Properties through Inhibition of Kinase Activity. LamoralTheys, D.; Pottier, L.; Dufrasne, F.; Neve, J.; Dubois, J.; Kornienko, A.; Kiss, R.; Ingrassia, L. Curr. Med. Chem. 2010, 17, 812.
33. Lycorine, the Main Phenanthridine Amaryllidaceae Alkaloid, Exhibits Significant Anti-Tumor Activity in Cancer Cells that Display Resistance to Proapoptotic Stimuli: an Investigation of Structure-Activity Relationship and Mechanistic Insight. Lamoral-Theys, D.; Andolfi, A.; Van Goietsenoven, G.; Cimmino, A.; Le Calvé, B.; Wauthoz, N.; Mégalizzi, V.; Gras, T.; Bruyère, C.; Dubois, J.; Mathieu, V.; Kornienko, A.; Kiss, R.; Evidente, A. J. Med. Chem. 2009, 52, 6244
32. Synthesis of Structurally Simplified Analogues of Pancratistatin: Truncation of the Cyclitol Ring. Manpadi, M.; Kireev, A. S.; Magedov, I. V.; Altig, J.; Tongwa, P.; Antipin, M. Y.; Evidente, A.; van Otterlo, W. A. L.; Kornienko, A. J. Org. Chem. 2009, 74, 7122.
31. Anticancer Evaluation of Structurally Diverse Amaryllidaceae Alkaloids and their Synthetic Derivatives. Evidente, A.; Kornienko, A. Phytochem. Rev. 2009, 8, 449.
30. Biological Evaluation of Structurally Diverse Amaryllidaceae Alkaloids and their Synthetic Derivatives: Discovery of Novel Leads for Anticancer Drug Design. Evidente, A.; Kireev, A. S.; Jenkins, A. R.; Romero, A. E.; Steelant, W. F. A.; Van slambrouck, S.; Kornienko, A. Planta Med. 2009, 75, 501.
29. Enantio- and Diastereodivergent Synthetic Route to Multifarious Cyclitols from D-Xylose via Ring-Closing Metathesis. Luchetti, G.; Ding, K.; d’Alarcao, M.; Kornienko, A. Synthesis 2008, 3142.
28. Synthesis of Differentially Protected myo- and chiro-Inositols from D-Xylose; Stereoselectivity in Intramolecular SmI2-Promoted Pinacol Reactions. Luchetti, G.; Ding, K.; Kornienko, A.; d’Alarcao, M. Synthesis 2008, 3148.
27. Chemistry, Biology and Medicinal Potential of Narciclasine and its Congeners. Kornienko, A.; Evidente, A. Chem. Rev. 2008, 108, 1982.
26. Novel Three-Component Synthesis and Antiproliferative Properties of Diversely Functionalized Pyrrolines. Magedov, I. V.; Luchetti, G.; Evdokimov, N. M.; Manpadi, M.; Steelant, W. F. A.; Van slambrouck, S.; Tongwa, P.; Antipin, M. Y.; Kornienko, A. Bioorg. Med. Chem. Lett. 2008, 18, 1392.
25. Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells. Sigstedt, S. C.; Hooten, C. J.; Callewaert, M. C.; Jenkins, A. R.; Romero, A. E.; Pullin, M. J.; Kornienko, A.; Lowrey, T. K.; Van slambrouck, S.; Steelant, W. F. A. Int. J. Oncol. 2008, 32, 1085.
24. Structural Simplification of Bioactive Natural Products with Multicomponent Synthesis. 2. Antiproliferative and Antitubulin Activities of Pyrano[3,2-c]pyridones and Pyrano[3,2-c]quinolones. Magedov, I. V.; Manpadi, M.; Ogasawara, M. A.; Dhawan, A. S.; Rogelj, S.; Van slambrouck, S.; Steelant, W. F. A.; Evdokimov, N. M.;
Uglinskii, P. Y.; Elias, E. M.; Knee, E. J.; Tongwa, P.; Antipin, M. Y.; Kornienko, A. J. Med. Chem. 2008, 51, 2561.
23. Total Syntheses of Pancratistatin. Manpadi, M.; Kornienko, A. Org. Prep. Proced. Int. 2008, 40, 107.
22. Structural Simplification of Bioactive Natural Products with Multicomponent Synthesis: Dihydropyridopyrazole Analogues of Podophyllotoxin. Magedov, I. V.; Manpadi, M.; Rozhkova, E.; Przheval’skii, N. M.; Rogelj, S.; Shors, S. T.; Steelant, W. F. A.; Van slambrouck, S.; Kornienko, A. Bioorg. Med. Chem. Lett. 2007, 17, 1381.
21. Effects of crude aqueous Medicinal Plant Extracts on growth and invasion of breast cancer cells. Van slambrouck, S.; Daniels, A. L.; Hooten, C. J.; Brock, S. L.; Jenkins A. R.; Ogasawara M. A.; Baker, J. M.; Adkins, G.; Elias E. M.; Agustin, V. J.; Constantine, S. R.; Pullin, M. J.; Shors, S. T.; Kornienko, A.; Steelant, W. F. A. Oncology Reports 2007, 17, 1487.
20. One-Step Synthesis of Heterocyclic Privileged Medicinal Scaffolds Using a Multicomponent Reaction of Malononitrile with Aldehydes and Thiols. Evdokimov, N. M; Kireev, A. S.;Yakovenko, A. A.; Antipin, M. Y.; Magedov, I. V.; Kornienko, A. J. Org. Chem. 2007, 72, 3443.
19. Antiproliferative and apoptosis inducing properties of pyrano[3,2-c]pyridones accessible by a one-step multicomponent synthesis. Magedov, I. V.; Manpadi, M.; Evdokimov, N. M.; Elias, E. M.; Rozhkova, E.; Ogasawara, M. A.; Bettale, J. D.; Przeval’skii, N. M.; Rogelj, S.; Kornienko, A. Bioorg. Med. Chem. Lett. 2007, 17, 3872.
18. Discovery and Investigation of Antiproliferative and Apoptosis-Inducing Properties of New Heterocyclic Podophyllotoxin Analogues Accessible by a One-Step Multicomponent Synthesis. Magedov, I.V.; Manpadi, M.; Van Slambrouck, S.; Steelant, W. F. A.; Rozhkova, E.; Przheval’skii, N. M.; Rogelj, S.; Kornienko, A. J. Med.
Chem. 2007, 50, 5183.
17. Three-component synthesis and anticancer evaluation of polycyclic indenopyridines lead to the discovery of a novel indenoheterocycle with potent apoptosis inducing properties. Manpadi, M.; Uglinskii, P. Y.; Rastogi, S. K.; Cotter, K. M.; Wong, Y-S. C.; Anderson, L. A.; Ortega, A. J.; Van slambrouck, S.; Steelant, W. F. A.; Rogelj, S.; Tongwa, P.; Antipin, M. Y.; Magedov, I. V.; Kornienko, A. Org. Biomol. Chem. 2007, 5, 3865.
16. One Step Three-Component Synthesis of Pyridines and 1,4-Dihydropyridines with Manifold Medicinal Utility. Evdokimov, N.M.; Magedov, I. V.; Kireev, A. S.; Kornienko, A. Org. Lett. 2006, 8, 899.
15. Selectivity Guidelines and a Reductive Elimination-Based Model for Predicting the Stereochemical Course of Conjugate Addition Reactions of Organocuprates to gamma-Alkoxy-alpha,beta-Enoates. Kireev, A. S.; Manpadi, M.; Kornienko, A. J. Org. Chem. 2006, 71, 2630.
14. Effects of extracts from two Native American plants on proliferation of human breast and colon cancer cell lines in vitro. Daniels, A. L.; Van slambrouck, S.; Lee, R. L.; Arguello, T. S.; Browning, J.; Pullin, M. J.; Kornienko, A.; Steelant, W. F. A. Oncology Reports, 2006, 15, 1327.
13. Synthesis and Biological Evaluation of Aromatic Analogues of Conduritol F, L-chiro-Inositol and Dihydroconduritol F Structurally Related to the Amaryllidaceae Anticancer Constituents. Kireev, A. S.; Nadein, O. N.; Agustin, V. J.; Bush, N. E.; Evidente, A.; Manpadi, M.; Ogasawara, M. A.; Rastogi, S. K.; Rogelj, S.; Shors, S. T.; Kornienko, A. J. Org. Chem. 2006, 71, 5694.
12. Convenient One-Step Synthesis of a Medicinally Relevant Benzopyranopyridine System. Evdokimov, N. M; Kireev, A. S.;Yakovenko, A. A.; Antipin, M. Y.; Magedov, I. V.; Kornienko, A. Tetrahedron Lett. 2006, 47, 9309.
11. A solution to the stereochemical problems posed by amaryllidaceae constituents using a highly syn-selective arylcuprate conjugate addition to gamma-amino and gamma-carbamato-alpha,beta-enoates. Rastogi, S. K.; Kornienko, A. Tetrahedron: Asymmetry, 2006, 17, 3170.
10. Enantiodivergent Formal Synthesis of (+)- and (-)-Cyclophellitol Based on the Latent Symmetry Concept. Kireev, A. S., Breithaupt, A. T.; Collins, W.; Nadein, O. N.; Kornienko, A. J. Org. Chem. 2005, 70, 742.
9. Highly anti selective conjugate addition of arylcuprates to a gamma-Alkoxy-alpha,beta-Enoate. A new method to address stereochemical challenges presented by Amaryllidaceae alkaloids. Manpadi, M.; Kornienko, A. Tetrahedron Lett. 2005, 46, 4433.
8. An Approach to Pancratistatins via Ring-Closing Metathesis: Efficient Synthesis of Novel 1-Aryl-1- deoxyconduritols F. Nadein, O. N.; Kornienko, A. Org. Lett. 2004, 6, 831.
7. Probing the functional requirements of the L-haba side-chain of amikacin – Synthesis, 16S A-Site rRNA binding, and antibacterial activity. Hanessian, S.; Kornienko, A.; Swayze, E. E. Tetrahedron 2003, 59, 995.
6. Design, modeling and synthesis of functionalized paromamine analogs. Hanessian, S.; Tremblay, M.; Kornienko, A.; Moitessier, N. Tetrahedron 2001, 57, 3255.
5. Synthesis of Cyclitols via Ring-Closing Metathesis. Kornienko, A.; d’Alarcao, M. Tetrahedron: Asymmetry 1999, 10, 827.
4. Practical Synthesis of a Differentially Protected myo-Inositol. Kornienko, A.; Turner, D. I.; Jaworek, C. H.; d’Alarcao, M. Tetrahedron: Asymmetry 1998, 9, 2783.
3. Synthesis of a Jojoba Bean Disaccharide. Kornienko, A.; Marnera, G.; d’Alarcao, M. Carbohydr. Res. 1998, 310, 141.
2. Enantiospecific Synthesis of a Differentially Protected L-chiro-Inositol from D-Xylose. Kornienko, A.; d’Alarcao, M. Tetrahedron Lett. 1997, 38, 6497.
1. A New Convenient Method to Obtain Pyrroles from Tertiary N-Allylthioamides. Magedov, I. V.; Kornienko, A. V.; Zotova, T. O.; Drozd, V. N. Tetrahedron Lett. 1995, 36, 4619.
Patents
6. Methods for treatment of resistant cancer. US 62/329,393. Pending.
5. Novel Polygodial Analogues for the Treatment of Cancer and other Proliferative Diseases. US 62/208,656. Pending.
4. Antibiotic sensitivity-restoring and photosensitive agents. US 62/149,738. Pending.
3. 2-Aryl-2-(3-indolyl)acetohydroxamates for the Treatment of Drug-Resistant Cancer. US 61/891,746 2013. Awarded.
2. Synthetic Rigidin Analogues as Anticancer Agents, Salts, Solvates and Prodrugs Thereof, and Method of Producing Same. US 08/946,246 2012. Awarded.
1. Pyrano[3,2-c]Pyridones and Related Heterocyclic Compounds as Pharmaceutical Agents for Treating Disorders Responsive to Apoptosis, Antiproliferation or Vascular Disruption, and the Use Thereof. US 12/407,358 2009. Awarded.